Here you may change the default hotkeys. Choose the menu item in the two top windows, place the cursor in the Press shortcut keys here field and do just that. If the hotkey chosen is already in use you will be prompted to chose another combination. Confirm by clicking Apply.
The hotkey definitions are stored in a text file named Keyboard config.txt in C:\Documents and Settings\[Username]\Application Data\Titlevision 2011 (XP) or C:\Users\[Username]\Appdata\Roaming\TitleVision 2011 (Vista, Win 7 and Win 8).
If the program crashes at startup after a hotkey redefinition, you have used keys that are not valid. It's hard to advise you which to avoid, since it differs from system to system, but known culprits are the Plus and Minus Keys on the Numpad. If this happens and you can't remember what changes to undo, click this link, copy all text under the horizontal line and paste it into the file named Keyboard config.txt in C:\Documents and Settings\[Username]\Application Data\Titlevision 2011 (XP) or C:\Users\[Username]\Appdata\Roaming\TitleVision 2011 (Vista, Win 7 and Win 8), making sure all previous text in that file is erased in the process.